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AutorRoca, Joaquim
Fecha de publicación1998
EditorJAI Press
CitaciónAdvances in Genome Biology (5): 463-486 (1998)
ResumenThis chapter describes topoisomerases. Much progress has been made in structural and functional studies on DNA topoisomerases. New enzymes of the topoisomerase family are still being discovered, and the biological implications of these enzymes stands under open discussion. The potential of DNA topoisomerases as drug targets has expanded this research field into the realm of pharmacology and clinical medicine. Some topics like the viral and mithocondrial topoisomerases remain largely unexplored. The chapter presents the current understanding on the structure and mechanism of these enzymes, and the biological roles of DNA topoisomerases in prokaryotic and eukaryotic cells. All known DNA topoisomerases share two characteristics. One is their ability to cleave and reseal the phosphodiester backbone of DNA in two successive transesterification reactions. The second characteristic is that once a topoisomerase-cleaved DNA intermediate is formed, the enzyme allows the severed DNA ends to come apart, opening a gate for the passage of another single- or double-stranded DNA segment
DescripciónCapítulo en: Ram S. Verma (ed.). Advances in Genome Biology, vol. 5B. [S.l.]: JAI Press, 1998, p.463-486. ISBN 0-7623-0079-5. ISBN 978-0-7623-0079-2
Identificadoresisbn: 0-7623-0079-5
isbn: 978-0-7623-0079-2
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