English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/116976
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Hepatocyte growth factor is elevated in amniotic fluid from obese women and regulates placental glucose and fatty acid metabolism

AutorVisiedo, Francisco; Bugatto, Fernando; Carrasco-Fernández, C.; Sáez-Benito, A.; Mateos, R. M.; Cózar-Castellano, Irene ; Bartha, Jose L.; Perdomo, Germán
Palabras claveGlucose metabolism
Hepatocyte growth factor
Fatty acid metabolism
Placental inflammation
Fecha de publicación2015
EditorElsevier
CitaciónPlacenta 36(4): 381-388 (2015)
Resumen[Introduction]: To evaluate the impact of the pro-inflammatory cytokine hepatocyte growth factor (HGF) on the regulation of glucose and lipid placental metabolism. [Methods]: HGF levels were quantified in amniotic fluid and placenta from control and obese women. 2-deoxy-glucose (2-DOG) uptake, glycolysis, fatty acid oxidation (FAO), fatty acid esterification, de novo fatty acid synthesis, triglyceride levels and carnitine palmitoyltransferase activities (CPT) were measured in placental explants upon addition of pathophysiological HGF levels. [Results]: In obese women, total- and -activated-HGF levels in amniotic fluid were elevated ∼24%, and placental HGF levels were ∼3-fold higher than in control women. At a similar dose to that present in amniotic fluid of obese women, HGF (30 ng/mL) increased Glut-1 levels and 2-DOG uptake by ∼25-30% in placental explants. HGF-mediated effect on 2-DOG uptake was dependent on the activation of phosphatidylinositol 3-kinase signaling pathway. In addition, HGF decreased ∼20% FAO, whereas esterification and de novo fatty acid synthesis increased ∼15% and ∼25% respectively, leading to 2-fold triglyceride accumulation in placental explants. In parallel, HGF reduced CPT-I activity ∼70%. [Discussion]: HGF is a cytokine elevated in amniotic fluid and placental tissue of obese women, which through its ability to stimulate 2-DOG uptake and metabolism impairs FAO and enhances esterification and de novo fatty acid synthesis, leading to accumulation of placental triglycerides.
Versión del editorhttp://dx.doi.org/10.1016/j.placenta.2015.01.199
URIhttp://hdl.handle.net/10261/116976
DOI10.1016/j.placenta.2015.01.199
Identificadoresdoi: 10.1016/j.placenta.2015.01.199
issn: 0143-4004
e-issn: 1532-3102
Aparece en las colecciones: (IBGM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Hepatocyte1growthfactor.pdf878,52 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.