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dc.contributor.authorGuijas, Carlos-
dc.contributor.authorRodríguez, Juan Pablo-
dc.contributor.authorRubio, Julio M.-
dc.contributor.authorBalboa, María A.-
dc.contributor.authorBalsinde, Jesús-
dc.date.accessioned2015-06-22T09:45:20Z-
dc.date.available2015-06-22T09:45:20Z-
dc.date.issued2014-
dc.identifierdoi: 10.1016/j.bbalip.2014.10.004-
dc.identifierissn: 1388-1981-
dc.identifier.citationBiochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1841(12): 1661-1671 (2014)-
dc.identifier.urihttp://hdl.handle.net/10261/116948-
dc.description.abstractThe classical regard of lipid droplets as mere static energy-storage organelles has evolved dramatically. Nowadays these organelles are known to participate in key processes of cell homeostasis, and their abnormal regulation is linked to several disorders including metabolic diseases (diabetes, obesity, atherosclerosis or hepatic steatosis), inflammatory responses in leukocytes, cancer development and neurodegenerative diseases. Hence, the importance of unraveling the cell mechanisms controlling lipid droplet biosynthesis, homeostasis and degradation seems evident. Phospholipase A2s, a family of enzymes whose common feature is to hydrolyze the fatty acid present at the sn-2 position of phospholipids, play pivotal roles in cell signaling and inflammation. These enzymes have recently emerged as key regulators of lipid droplet homeostasis, regulating their formation at different levels. This review summarizes recent results on the roles that various phospholipase A2 forms play in the regulation of lipid droplet biogenesis under different conditions. These roles expand the already wide range of functions that these enzymes play in cell physiology and pathophysiology.-
dc.description.sponsorshipWork in our laboratories was supported by the Spanish Ministry of Science and Innovation (Grants BFU2010-18826, SAF2010-18831, and SAF2013-48201-R), and the Education Department of the Autonomous Government of Castile and Leon (Grant CSI007U13). C. G. was supported by a predoctoral fellowship from the University of Valladolid. CIBERDEM is an initiative of Instituto de Salud Carlos III.-
dc.publisherElsevier-
dc.relation.isversionofPostprint-
dc.rightsopenAccess-
dc.subjectLipid droplet-
dc.subjectArachidonic acid-
dc.subjectLipid mediator-
dc.subjectInflammation-
dc.subjectPhospholipase A2-
dc.titlePhospholipase A2 regulation of lipid droplet formation-
dc.typeartículo-
dc.identifier.doi10.1016/j.bbalip.2014.10.004-
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.bbalip.2014.10.004-
dc.date.updated2015-06-22T09:45:21Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderJunta de Castilla y León-
dc.contributor.funderUniversidad de Valladolid-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100007515es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100014180es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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