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Delphinidin activates NFAT and induces IL-2 production through SOCE in T cells

AutorJara, Evelyn; Hidalgo, María A.; Hancke, Juan L.; Hidalgo, Alejandra I.; Brauchi, Sebastian; Nuñez, Luisa; Villalobos, Carlos ; Burgos, Rafael A.
Palabras claveNFAT
Cytokines
T cells
Calcium
Delphinidin
Fecha de publicación2014
EditorSpringer
CitaciónCell Biochemistry and Biophysics 68(3): 497-509 (2014)
ResumenDelphinidin is an anthocyanidin that possesses antioxidant and anti-inflammatory effects; however, some reports suggest that delphinidin has pro-inflammatory properties. For this reason, we assessed the effect of delphinidin on cytokine production in T cells. We demonstrated that delphinidin increased the cytosolic-free Ca2+ concentration by releasing Ca2+ from intracellular stores and increasing Ca2+ entry. The putative Ca2+ release activated Ca2+ (CRAC) channel inhibitors BTP2 and gadolinium reduced the calcium entry stimulated by the anthocyanidin. Delphinidin induced nuclear factor of activated T cells (NFAT) translocation and NFAT-Luc activity in Jurkat cells and was dependent on the CRAC channel and calcineurin pathway. Delphinidin increased the mRNA expression and production of IL-2 in Jurkat cells and was inhibited by BTP2 and cyclosporine A. Using peripheral blood lymphocytes, we demonstrated that delphinidin increased the production of IL-2 and IFN-¿ and was inhibited by BTP2. Taken together, our results suggest that delphinidin exerts immunostimulatory effects on T cells by increasing cytokine production through CRAC channel and NFAT activation. © 2013 Springer Science+Business Media New York.
URIhttp://hdl.handle.net/10261/116895
DOI10.1007/s12013-013-9728-z
Identificadoresdoi: 10.1007/s12013-013-9728-z
issn: 1085-9195
e-issn: 1559-0283
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