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Title

Unfractionated heparin is associated with a lower rise of serum vascular cell adhesion molecule-1 in acute ischemic stroke patients

AuthorsChamorro, Ángel; Cervera, Álvaro; Castillo, José; Dávalos, Antoni; Aponte, John Jairo; Planas, Anna M.
KeywordsVascular cell adhesion molecule-1
Outcome
Inflammation
Heparin
Cytokines
Cerebrovascular disease
spirin
Issue Date16-Aug-2002
PublisherElsevier
CitationNeuroscience Letters 328(3): 229-232 (2002)
AbstractWe sought to assess the anti-inflammatory properties of unfractionated heparin (UFH) in patients with ischemic stroke treated within 24 h from the onset of symptoms. We studied prospectively 167 patients that received 1000 IU/h intravenous UFH (n=70) or 300 mg oral aspirin (n=97) at a mean treatment delay of 6.7 h. Repeated plasma levels of interleukin (IL)-6, IL-10, IL-4, tumor necrosis factor (TNF)-α, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) were compared in both groups using multivariate analyses. Whereas TNF-α and sICAM-1 decreased at 48 h, IL-6, IL-4, and sVCAM-1 increased compared with baseline values (P<0.01). The rise of sVCAM-1 levels at 48 h was significantly lower in patients treated with UFH (P=0.017) and a two-fold increase of baseline sVCAM-1 was an independent predictor of poor outcome (odds ratio, 2.19, 1.1-4.39). These results suggest that adjusted high-dose UFH has anti-inflammatory effects which might improve recovery if administered early after stroke onset. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Publisher version (URL)http://dx.doi.org/10.1016/S0304-3940(02)00518-9
URIhttp://hdl.handle.net/10261/116860
DOI10.1016/S0304-3940(02)00518-9
Identifiersdoi: 10.1016/S0304-3940(02)00518-9
issn: 0304-3940
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