English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/116832
Título

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

AutorMeseguer, Víctor M.; Tajada, Sendoa; Denlinger, Bristol L.; Fajardo, Otto; Manenschijn, Jan-Albert; Fernández-Peña, Carlos; Pérez-García, M. Teresa ; López-López, José R. ; Voets, Thomas; Belmonte, Carlos; Talavera, Karel; Viana, Félix
Fecha de publicación2014
EditorNature Publishing Group
CitaciónNature Communications 5: 3125 (2014)
ResumenGram-negative bacterial infections are accompanied by inflammation and somatic or visceral pain. These symptoms are generally attributed to sensitization of nociceptors by inflammatory mediators released by immune cells. Nociceptor sensitization during inflammation occurs through activation of the Toll-like receptor 4 (TLR4) signalling pathway by lipopolysaccharide (LPS), a toxic by-product of bacterial lysis. Here we show that LPS exerts fast, membrane delimited, excitatory actions via TRPA1, a transient receptor potential cation channel that is critical for transducing environmental irritant stimuli into nociceptor activity. Moreover, we find that pain and acute vascular reactions, including neurogenic inflammation (CGRP release) caused by LPS are primarily dependent on TRPA1 channel activation in nociceptive sensory neurons, and develop independently of TLR4 activation. The identification of TRPA1 as a molecular determinant of direct LPS effects on nociceptors offers new insights into the pathogenesis of pain and neurovascular responses during bacterial infections and opens novel avenues for their treatment. © 2014 Macmillan Publishers Limited. All rights reserved.
DescripciónThis work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.-- et al.
Versión del editorhttp://dx.doi.org/10.1038/ncomms4125
URIhttp://hdl.handle.net/10261/116832
DOI10.1038/ncomms4125
Identificadoresdoi: 10.1038/ncomms4125
e-issn: 2041-1723
Aparece en las colecciones: (IBGM) Artículos
(IN) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
TRPA1 channels.pdf1,73 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.