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Título

Presence of heat shock protein 70 in secondary lymphoid tissue correlates with stroke prognosis

AutorGómez-Choco, Manuel; Doucerain, Cédric; Urra, Xabier; Planas, Anna M. ; Chamorro, Ángel
Palabras claveAcute stroke
Antigen presentation
Heat shock protein
Neuroimmunology
Lymphoid tissue
Fecha de publicación2014
EditorElsevier
CitaciónJournal of Neuroimmunology 270(1-2): 67-74 (2014)
ResumenHeat shock protein 70 (Hsp-70) can act as a danger signal and activate immune responses. We studied the presence of Hsp-70 in lymphoid tissue and plasma of acute stroke patients and asymptomatic controls free of neurological disease. Immunofluorescence, Western blotting, qRT-PCR and flow cytometry studies were performed. Plasma Hsp-70 concentration at day 7 was similar in patients and controls, whereas patients disclosed stronger immunoreactivity to Hsp-70 in lymphoid tissue than controls. Most Hsp-70. + cells were antigen presenting cells located in T cell zones. Stronger immunoreactivity to Hsp-70 was associated with smaller infarctions and better functional outcome. © 2014 Elsevier B.V.
Versión del editorhttp://dx.doi.org/10.1016/j.jneuroim.2014.03.004
URIhttp://hdl.handle.net/10261/116808
DOI10.1016/j.jneuroim.2014.03.004
Identificadoresdoi: 10.1016/j.jneuroim.2014.03.004
issn: 1872-8421
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