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Presence of heat shock protein 70 in secondary lymphoid tissue correlates with stroke prognosis

AuthorsGómez-Choco, Manuel; Doucerain, Cédric; Urra, Xabier; Planas, Anna M. ; Chamorro, Ángel
KeywordsAcute stroke
Antigen presentation
Heat shock protein
Lymphoid tissue
Issue Date2014
CitationJournal of Neuroimmunology 270(1-2): 67-74 (2014)
AbstractHeat shock protein 70 (Hsp-70) can act as a danger signal and activate immune responses. We studied the presence of Hsp-70 in lymphoid tissue and plasma of acute stroke patients and asymptomatic controls free of neurological disease. Immunofluorescence, Western blotting, qRT-PCR and flow cytometry studies were performed. Plasma Hsp-70 concentration at day 7 was similar in patients and controls, whereas patients disclosed stronger immunoreactivity to Hsp-70 in lymphoid tissue than controls. Most Hsp-70. + cells were antigen presenting cells located in T cell zones. Stronger immunoreactivity to Hsp-70 was associated with smaller infarctions and better functional outcome. © 2014 Elsevier B.V.
Publisher version (URL)http://dx.doi.org/10.1016/j.jneuroim.2014.03.004
Identifiersdoi: 10.1016/j.jneuroim.2014.03.004
issn: 1872-8421
Appears in Collections:(IIBB) Artículos
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