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Title

Middle cerebral artery remodeling following transient brain ischemia is linked to early postischemic hyperemia: A target of uric acid treatment

AuthorsOnetti, Yara; Dantas, A. P.; Pérez, Belén ; Cugota, Roger; Chamorro, Ángel; Planas, Anna M. ; Vila, Elisabet; Jiménez-Altayó, Francesc
KeywordsPeroxynitrite
Oxidative stress
Interleukin-18
Ischemia-reperfusion
Macrophages
Issue Date2015
PublisherAmerican Physiological Society
CitationAmerican Journal of Physiology - Heart and Circulatory Physiology 308(8): H862-H874 (2015)
Abstract© 2015 the American Physiological Society. Ischemia impairs blood supply to the brain, and reperfusion is important to restore cerebral blood flow (CBF) and rescue neurons from cell death. However, reperfusion can induce CBF values exceeding the basal values before ischemia. This hyperemic effect has been associated with a worse ischemic brain damage, albeit the mechanisms that contribute to infarct expansion are not clear. In this study, we investigated the influence of early postischemic hyperemia on brain damage and middle cerebral artery (MCA) properties and the effect of treatment with the endogenous antioxidant uric acid (UA). The MCA was occluded for 90 min followed by 24 h reperfusion in adult male Sprague-Dawley rats. Cortical CBF increases at reperfusion beyond 20% of basal values were taken as indicative of hyperemia. UA (16 mg/kg) or vehicle (Locke's buffer) was administered intravenously 135 min after MCA occlusion. Hyperemic compared with nonhyperemic rats showed MCA wall thickening (sham: 22.4 ± 0.8 μm; nonhyperemic: 23.1 ± 1.2 μm; hyperemic: 27.8 ± 0.9 at 60 mmHg; P < 0.001, hyperemic vs. sham) involving adventitial cell proliferation, increased oxidative stress, and interleukin-18, and more severe brain damage. Thus MCA remodeling after ischemia-reperfusion takes place under vascular oxidative and inflammatory stress conditions linked to hyperemia. UA administration attenuated MCA wall thickening, induced passive lumen expansion, and reduced brain damage in hyperemic rats, although it did not increase brain UA concentration. We conclude that hyperemia at reperfusion following brain ischemia induces vascular damage that can be attenuated by administration of the endogenous antioxidant UA.
Publisher version (URL)http://dx.doi.org/10.1152/ajpheart.00001.2015
URIhttp://hdl.handle.net/10261/116800
DOI10.1152/ajpheart.00001.2015
Identifiersdoi: 10.1152/ajpheart.00001.2015
issn: 1522-1539
Appears in Collections:(IIBB) Artículos
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