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dc.contributor.authorChamorro, Ángel-
dc.contributor.authorAmaro, Sergio-
dc.contributor.authorVargas, Martha-
dc.contributor.authorObach, Víctor-
dc.contributor.authorCervera, Álvaro-
dc.contributor.authorTorres, Ferran-
dc.contributor.authorPlanas, Anna M.-
dc.identifierdoi: 10.1136/jnnp.2006.100800-
dc.identifierissn: 0022-3050-
dc.identifier.citationJournal of Neurology, Neurosurgery and Psychiatry 77(11): 1279-1281 (2006)-
dc.description.abstractBackground and purpose: The pathophysiology of stroke-associated infection (SAI) is uncertain. The cytokine profile and peripheral white cell response were assessed in patients with or without SAI. Methods: The incidence of SAI was assessed in 110 patients with ischaemic stroke allocated antibiotic prophylaxis or placebo within 24 h of clinical onset. Peripheral white cell counts, interleukin (IL)6, tumour necrosis factor (TNF)α and IL10 were measured in plasma. Results: 17 (15%) patients developed infection and showed time-dependent increases of total white cell count, neutrophils, monocytes, lymphocytes, IL6 and IL10, whereas TNFα and the TNFα/IL10 ratio decreased. In logistic regression, IL10 (odds ratio (OR) 1.08, 95% confidence interval (CI) 1.01 to 1.16), monocyte count (OR 1.42, 95% CI 1.08 to 1.87) and National Institute for Health Stroke Survey score on admission (OR 1.17, 95% CI 1.05 to 1.31) were independent predictors of systemic infection. Conclusions: SAI is associated with stroke severity, excessive IL10-mediated response and an increased number of circulating monocytes. These results support the finding that acute ischaemic brain injury triggers a blood-borne anti-inflammatory response that decreases the antimicrobial drive of the immune system.-
dc.description.sponsorshipThis study was in part supported by a grant from the Fondo Investigaciones Sanitarias (FIS 02/0477), Spanish Ministry of Health-
dc.publisherBMJ Publishing Group-
dc.titleInterleukin 10, monocytes and increased risk of early infection in ischaemic stroke-
dc.description.versionPeer Reviewed-
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