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http://hdl.handle.net/10261/116782
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Chamorro, Ángel | - |
dc.contributor.author | Amaro, Sergio | - |
dc.contributor.author | Vargas, Martha | - |
dc.contributor.author | Obach, Víctor | - |
dc.contributor.author | Cervera, Álvaro | - |
dc.contributor.author | Torres, Ferran | - |
dc.contributor.author | Planas, Anna M. | - |
dc.date.accessioned | 2015-06-18T09:22:29Z | - |
dc.date.available | 2015-06-18T09:22:29Z | - |
dc.date.issued | 2006-11 | - |
dc.identifier | doi: 10.1136/jnnp.2006.100800 | - |
dc.identifier | issn: 0022-3050 | - |
dc.identifier.citation | Journal of Neurology, Neurosurgery and Psychiatry 77(11): 1279-1281 (2006) | - |
dc.identifier.uri | http://hdl.handle.net/10261/116782 | - |
dc.description.abstract | Background and purpose: The pathophysiology of stroke-associated infection (SAI) is uncertain. The cytokine profile and peripheral white cell response were assessed in patients with or without SAI. Methods: The incidence of SAI was assessed in 110 patients with ischaemic stroke allocated antibiotic prophylaxis or placebo within 24 h of clinical onset. Peripheral white cell counts, interleukin (IL)6, tumour necrosis factor (TNF)α and IL10 were measured in plasma. Results: 17 (15%) patients developed infection and showed time-dependent increases of total white cell count, neutrophils, monocytes, lymphocytes, IL6 and IL10, whereas TNFα and the TNFα/IL10 ratio decreased. In logistic regression, IL10 (odds ratio (OR) 1.08, 95% confidence interval (CI) 1.01 to 1.16), monocyte count (OR 1.42, 95% CI 1.08 to 1.87) and National Institute for Health Stroke Survey score on admission (OR 1.17, 95% CI 1.05 to 1.31) were independent predictors of systemic infection. Conclusions: SAI is associated with stroke severity, excessive IL10-mediated response and an increased number of circulating monocytes. These results support the finding that acute ischaemic brain injury triggers a blood-borne anti-inflammatory response that decreases the antimicrobial drive of the immune system. | - |
dc.description.sponsorship | This study was in part supported by a grant from the Fondo Investigaciones Sanitarias (FIS 02/0477), Spanish Ministry of Health | - |
dc.publisher | BMJ Publishing Group | - |
dc.rights | closedAccess | - |
dc.title | Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1136/jnnp.2006.100800 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1136/jnnp.2006.100800 | - |
dc.date.updated | 2015-06-18T09:22:29Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.identifier.pmid | 17043295 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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