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Xanthine dehydrogenase (Xdh): Episodic evolution of a "neutral" protein

AutorRodríguez-Trelles, Francisco; Tarrío, Rosa ; Ayala, Francisco J.
Palabras claveHeterogeneous nucleotide composition
Molecular clock
Fluctuating mutation bias
Isochores
Lineage effects
XDH protein evolution
Fecha de publicación2001
EditorSpringer
CitaciónJournal of Molecular Evolution 53 (4-5): 485- 495 (2001)
ResumenWe investigated the evolution of xanthine dehydrogenase (Xdh) in 34 species from the three multicellular kingdoms, including one plant, two fungi, and three animal phyla, two classes of vertebrates, four orders of mammals, and two orders of insects. We adopted a model-based maximum-likelihood framework of inference. After accounting for among-site rate variation and heterogeneous nucleotide composition of the sequences using the discrete gamma distribution, and using nonhomogeneous nonstationary representations of the substitution process, the rate of amino acid replacement is 30.4 × 10-10/site/year when Drosophila species are compared but only ≈18 × 10-10/site/year when comparisons are made between mammal orders, between insect orders, or between different animal phyla and ≈11 × 10-10/site/year when comparisons are made between birds and mammals, between fungi, or between the three multicellular kingdoms. To account for these observations, the rate of amino acid replacement must have been eight or more times higher in some lineages and at some times than in others. Spastic evolution of Xdh appears to be related to the particularities of the genomes in which the locus is embedded.
Versión del editorhttp://dx.doi.org/10.1007/s002390010239
URIhttp://hdl.handle.net/10261/116770
DOI10.1007/s002390010239
Identificadoresdoi: 10.1007/s002390010239
issn: 0022-2844
e-issn: 1432-1432
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