Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/116746
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Induction of Stat3, a signal transducer and transcription factor, in reactive microglia following transient focal cerebral ischaemia |
Autor: | Planas, Anna M. CSIC ORCID; Soriano, Marc A.; Berruezo, Meritxell; Justicia, Carles CSIC ORCID; Estrada, Anna; Pitarch, Silvia; Ferrer, Isidro | Palabras clave: | Brain Lectin Middle cerebral artery occlusion Rat Stat3 |
Fecha de publicación: | 1996 | Editor: | Blackwell Publishing | Citación: | European Journal of Neuroscience 8(12): 2612-2618 (1996) | Resumen: | Stat3, a member of the family of cytoplasmic signal transducers and activators of transcription, was found in the rat brain in vivo under physiological conditions and was stimulated following transient focal cerebral ischaemia. A transient episode of middle cerebral artery occlusion induced a strong microglial response in the areas undergoing neural cell death from 4 days after middle cerebral artery occlusion. This was accompanied by increased expression of Stat3 in the ipsilateral cortex and striatum, as revealed by Western blotting of tissue extracts. Immunohistochemistry showed strong induction of Stat3 in reactive microglial cells 4, 7 and 15 days after cerebral ischaemia. Stat3 was seen in the microglia cytoplasm, but in many microglial cells immunoreactivity was also distributed within the nucleus. These results suggest that Stat3 mediates signal transduction and activates transcription in reactive microglia in vivo following brain ischaemia. | Versión del editor: | http://dx.doi.org/10.1111/j.1460-9568.1996.tb01556.x | URI: | http://hdl.handle.net/10261/116746 | DOI: | 10.1111/j.1460-9568.1996.tb01556.x | Identificadores: | doi: 10.1111/j.1460-9568.1996.tb01556.x issn: 0953-816X |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
96
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
93
checked on 28-feb-2024
Page view(s)
267
checked on 24-abr-2024
Download(s)
130
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.