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Título

Induction of cyclooxygenase-2 in the rat brain after a mild episode of focal ischemia without tissue inflammation or neural cell damage

AutorPlanas, Anna M. ; Soriano, Marc A.; Justicia, Carles ; Rodríguez-Farré, Eduard
Palabras claveCOX-2
Edema
Stroke
Middle cerebral artery occlusion
Rat
Infarct
Fecha de publicación12-nov-1999
EditorElsevier
CitaciónNeuroscience Letters 275(2): 141-144 (1999)
ResumenCyclooxygenase-2, a key enzyme in prostanoid synthesis, is induced by inflammatory stimuli and it is associated with cell death after cerebral ischemia. Here we evaluated whether cyclooxygenase-2 was induced after a short (10-min) episode of focal ischemia, mild enough not to cause inflammation or cell death. One-hour ischemia leading to brain infarct was studied for comparative purposes. Induction of cyclooxygenase-2 mRNA and protein was detected after both 10-min and 1-h ischemia. However, signs of edema were only apparent after 1-h, but not 10-min ischemia, and only rats subjected to 1-h ischemia had developed brain infarct at 4 days. Therefore, cyclooxygenase-2, not linked with neural cell death or inflammation, is induced after focal ischemia.
URIhttp://hdl.handle.net/10261/116743
DOI10.1016/S0304-3940(99)00756-9
Identificadoresdoi: 10.1016/S0304-3940(99)00756-9
issn: 0304-3940
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