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Dynamycs of Proinflammatory Ly6Chi Monocytes with Immunosuppressive Features after Brain Ischemia in Mice

AuthorsMiró-Mur, Francesc; Pérez-de-Puig, Isabel ; Ferrer-Ferrer, Maura; Urra, Xabier; Justicia, Carles ; Chamorro, Ángel; Planas, Anna M.
Issue Date22-Oct-2014
CitationIX Simposi de Neurobiologia Experimental (2014)
AbstractWe investigated the responses of different monocyte subsets to stroke in a model of permanent middle cerebral artery occlusion in mice. Using strategies of adoptive transfer of reporter monocytes and monocyte depletion we show that stroke promotes the maturation of Ly6Chi monocytes to non-classic Ly6CloCD43hiCCR2- monocytes and stimulates the release of immature Ly6Chi from body reservoirs to the blood. Ly6Chi monocytes secreted cytokines after activation, showed high phagocytic activity, and were able to inhibit T cell proliferation, showing that they had proinflammatory but also direct immunosuppressive properties. The Ly6ChiCD43loCCR2+ cells were the predominant monocytes recruited to the ischemic tissue where they acquired features of macrophages over time. Acute pharmacologic CCR2 blockade reduced infarct volume showing that proinflammatory Ly6Chi monocyte infiltration in the acute phase of stroke is detrimental. However, stroke also increased Ly6Chi monocyte numbers in the spleen where the observed immunosuppressive features suggest they can control T cell reactivity
DescriptionComunicación presentada en el IX Simposi de Neurobiologia Experimental, celebrado los días 22 y 23 de octubre de 2014 en Barcelona y organizado por la Societat Catalana de Biologia del Institut d'Estudis Catalans
Appears in Collections:(IIBB) Comunicaciones congresos
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