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Study of neurotoxic intracellular calcium signalling triggered by amyloids.

AuthorsVillalobos, Carlos ; Caballero, Erica ; Sanz-Blasco, Sara; Núñez, Lucía
KeywordsAmyloid β peptide
Bioluminescence imaging
Issue Date2012
CitationAmyloid Proteins. Methods and Protocols (Cap.20): 289-302 (2012)
SeriesMethods in Molecular Biology 849
AbstractNeurotoxicity in Alzheimer's disease (AD) is associated to dishomeostasis of intracellular Ca(2+) induced by amyloid β peptide (Aβ) species. Understanding of the effects of Aβ on intracellular Ca(2+) homeostasis requires preparation of the different Aβ assemblies including oligomers and fibrils and the testing of their effects on cytosolic and mitochondrial Ca(2+) in neurons. Procedures for cerebellar granule cell culture, preparation of Aβ species as well as fluorescence and bioluminescence imaging of cytosolic and mitochondrial Ca(2+) in neurons are described.
Publisher version (URL)http://dx.doi.org/10.1007/978-1-61779-551-0_20
Identifiersdoi: 10.1007/978-1-61779-551-0_20
isbn: 978-1-61779-550-3
Appears in Collections:(IBGM) Libros y partes de libros
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