English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/116665
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Cortical infarct volume is dependent on the ischemic reduction of perifocal cerebral blood flow in a three-vesel intraluminal MCA occlusion/reperfusion model in the rat

AuthorsSoriano, Marc A.; Sanz, Olga; Ferrer, Isidre; Planas, Anna M.
Keywordscerebral blood flow
cerebral ischemia
middle cerebral artery
laser-Doppler flowmetry
Issue Date7-Feb-1997
CitationBrain Research 747(2): 273-278 (1997)
AbstractOcclusion of the middle cerebral artery (MCA) causes a reduction of cerebral blood flow (CBF), which shows a progressive decrease from the periphery to the core of the MCA territory. The severity of ischemia is dependent on the duration of the ischemic episode and degree of CBF reduction. Fixing the ischemic episode to 1 h, we have examined whether or not cortical infarct size was related to the degree of CBF reduction in a perifocal cortical area in rats. One-hour intraluminal MCA occlusion accompanied with bilateral common carotid artery (CCA) occlusion (three-vessel occlusion/reperfusion model) was carried out in Sprague-Dawley rats and CBF was monitored with laser-Doppler flowmetry in the fronto-parietal cortex, an area which is perifocal to the core of the MCA territory. Finally, infarct size was measured 7 days later and was related to the corresponding CBF decrease. Sequential ipsilateral CCA, MCA and contralateral CCA occlusions produced reductions of CBF to 96%, 52% and 33% of baseline, respectively. Cortical infarct volume was found to be dependent on the corresponding reduction of perifocal cortical CBF during the ischemic episode. These results show that the reduction of CBF in the periphery of the MCA territory during 1-h focal ischemia determines infarct size in a three-vessel occlusion/reperfusion model.
Publisher version (URL)http://dx.doi.org/10.1016/S0006-8993(96)01285-1
Identifiersdoi: 10.1016/S0006-8993(96)01285-1
issn: 0006-8993
Appears in Collections:(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.