English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/116655
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Carboxyl-terminal fragment of amyloid precursor protein and hydrogen peroxide induce neuronal cell death through different pathways

AuthorsSebastià, Jordi; Pertusa, María; Vilchez, David; Planas, Anna M. ; Verbeek, R.; Rodríguez-Farré, Eduard; Cristòfol, Rosa ; Sanfeliu, Coral
KeywordsHydrogen peroxide
Alzheimer disease
Oxidative stress
Neurotoxicity
Carboxyl-terminal fragment of APP
Issue Date6-Jun-2006
PublisherSpringer
CitationJournal of Neural Transmission 113(12): 1837-1845 (2006)
AbstractCarboxyl-terminal fragments (CTs) of the amyloid precursor protein have been shown to be highly neurotoxic and are though to contribute to the neuropathology of Alzheimer's disease. We compared the effects of expressing CT99 in the human neuroblastoma MC65 with the effects of hydrogen peroxide on the parental SK-N-MC cells. CT99 and hydrogen peroxide generated a different pattern of free radicals and their toxic effects were differentially protected by a battery of antioxidants. Hydrogen peroxide caused a cell cycle arrest at phase S and apoptosis mediated through caspase-3 activation in a pattern similar to that described for amyloid-β neurotoxicity. However, CT99 apoptosis appeared to be mediated through an unidentified mitochondrial pathway. Both oxidative injury types induced heme oxygenase-1 expression as a neuroprotective response. Overall we found a coincidence in the nonespecific stress oxidative effects of CT99 and hydrogen peroxide, but clear differences on their respective potencies and pathways of neurotoxicity. © 2006 Springer-Verlag.
Publisher version (URL)http://dx.doi.org/10.1007/s00702-006-0492-8
URIhttp://hdl.handle.net/10261/116655
DOI10.1007/s00702-006-0492-8
Identifiersdoi: 10.1007/s00702-006-0492-8
issn: 0300-9564
Appears in Collections:(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.