English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/116628
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Administration of transforming growth factor-α reduces infarct volume after transient focal cerebral ischemia in the rat

AutorJusticia, Carles ; Pérez-Asensio, Fernando J. ; Burguete, María C.; Salom, Juan B.; Planas, Anna M.
Palabras claveMiddle cerebral artery occlusion
Rabbit
Rat
Microvascular perfusion
Growth factors
Fecha de publicación2001
EditorLippincott Williams & Wilkins
CitaciónJournal of Cerebral Blood Flow and Metabolism 21(9): 1097-1104 (2001)
ResumenGrowth factors promote cell growth and survival and protect the brain from developing injury after ischemia. In this article, the authors examined whether transforming growth factor-α (TGF-α was protective in transient focal ischemia and whether alteration of cerebral circulation was involved. Rats received intraventricular TGF-α (50 ng, either split into 2 doses given 30 minutes before and 30 minutes after middle cerebral artery occlusion (MCAO), or 1 dose given 30 minutes after MCAO) or vehicle. Rats were subjected to 1-hour intraluminal MCAO and cerebral blood flow was recorded continuously by laser-Doppler flowmetry. Infarct volume was measured 1 and 4 days later. The effects of TGF-α on arterial tone were assessed in isolated rabbit basilar and common carotid arteries. Transforming growth factor-α before and after ischemia reduced infarct volume by 70% at 1 day and 50% at 4 days. Transforming growth factor-α given only after ischemia also did reduce infarct volume by 70% at 1 day and 80% at 4 days. The protective effect was more marked in cortex than in striatum. Transforming growth factor-α did not change cortical microvascular perfusion and did not modify arterial passive tone nor agonist-induced active tone. It can be concluded that TGF-α reduces infarct volume, even when the factor is exclusively administered at reperfusion, and that this effect is not mediated by changes in microvascular perfusion or cerebral arteries. It is therefore suggested that TGF-α has a protective effect against neuronal cell death after transient focal ischemia.
Versión del editorhttp://dx.doi.org/10.1097/00004647-200109000-00007
URIhttp://hdl.handle.net/10261/116628
DOI10.1097/00004647-200109000-00007
Identificadoresissn: 0271-678X
Aparece en las colecciones: (IIBB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.