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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/116566
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dc.contributor.authorGarcía-Rostan, Ginesa-
dc.contributor.authorSalerno, Paolo-
dc.contributor.authorAlvarez Gago, Tomas-
dc.contributor.authorSantoro, Massimo-
dc.date.accessioned2015-06-15T09:25:47Z-
dc.date.available2015-06-15T09:25:47Z-
dc.date.issued2012-
dc.identifierdoi: 10.1530/ERC-12-0031-
dc.identifierissn: 1351-0088-
dc.identifiere-issn: 1479-6821-
dc.identifier.citationEndocrine-Related Cancer 19(5): 695-710 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/116566-
dc.descriptionPMID:22919068.-- et al.-
dc.description.abstractAnaplastic thyroid carcinoma (ATC) is a very aggressive thyroid cancer. forkhead box protein M1 (FOXM1) is a member of the forkhead box family of transcription factors involved in control of cell proliferation, chromosomal stability, angiogenesis, and invasion. Here, we show that FOXM1 is significantly increased in ATCs compared with normal thyroid, well-differentiated thyroid carcinomas (papillary and/or follicular), and poorly differentiated thyroid carcinomas (P=0.000002). Upregulation of FOXM1 levels in ATC cells was mechanistically linked to loss-of-function of p53 and to the hyperactivation of the phosphatidylinositol-3-kinase/AKT/FOXO3a pathway. Knockdown of FOXM1 by RNA interference inhibited cell proliferation by arresting cells in G2/M and reduced cell invasion and motility. This phenotype was associated with decreased expression of FOXM1 target genes, like cyclin B1 (CCNB1), polo-like kinase 1 (PLK1), Aurora B (AURKB), S-phase kinase-associated protein 2 (SKP2), and plasminogen activator, urokinase: uPA (PLAU). Pharmacological inhibition of FOXM1 in an orthotopic mouse model of ATC reduced tumor burden and metastasization. All together, these findings suggest that FOXM1 represents an important player in thyroid cancer progression to the anaplastic phenotype and a potential therapeutic target for this fatal cancer.-
dc.description.sponsorshipThis study was supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC), the Ministero dell'Università e della Ricerca (MiUR), and by the grant MERIT of MIUR. G Garcia-Rostan is supported by Programa Ramón y Cajal, Ministerio de Ciencia e Innovación, Social EU Funds, Universidad de Valladolid, Spain. C Nucera (Principal Investigator, Program: Human Thyroid Cancers Preclinical and Translational Research) was funded by the NIHR21CA165039-01A1 and the American Thyroid Association for Thyroid Cancer Research.-
dc.publisherSociety for Endocrinology-
dc.relation.isversionofPostprint-
dc.rightsopenAccess-
dc.titleFOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma-
dc.typeartículo-
dc.identifier.doi10.1530/ERC-12-0031-
dc.relation.publisherversionhttp://dx.doi.org/10.1530/ERC-12-0031-
dc.date.updated2015-06-15T09:25:47Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderAssociazione Italiana per la Ricerca sul Cancro-
dc.contributor.funderMinistero dell'Istruzione, dell'Università e della Ricerca-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderEuropean Commission-
dc.contributor.funderUniversidad de Valladolid-
dc.contributor.funderAmerican Thyroid Association-
dc.contributor.funderNational Institute for Health Research (UK)-
dc.contributor.funderCancer Research UK-
dc.relation.csicSí-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100005010es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003407es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100007515es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100002608es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000272es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000289es_ES
dc.identifier.pmid22919068-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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