English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/116498
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Protective effects of exogenous fructose-1,6-biphosphate during small bowel transplantation in rats

AuthorsSolà, Anna M. ; Oca, Javier de; Alfaro, Vicente; Xaus, Carme ; Jaurrieta, Eduardo; Hotter, Georgina
Issue DateMay-2004
PublisherMosby
CitationSurgery 135(5): 518-526 (2004)
AbstractBackground. We assessed the effect of adding exogenous fructose-1,6- biphosphate (F16BP) to the preservation solution (University of Wisconsin storage solution) used during an experimental procedure of small bowel transplantation in rats. Methods. We studied levels of the nucleotides hypoxanthine/xanthine and adenosine in tissue after cold ischemia, as well as histologic changes and associated deleterious processes such as bacterial translocation produced by the reperfusion associated with the transplantation. Results. The groups of rats treated with F16BP showed the lowest levels of hypoxanthine/xanthine and uric acid, the highest levels of adenosine, and the lowest levels of histologic damage and lactate dehydrogenase release to the bloodstream. Consumption of intestinal hypoxanthine during reperfusion was lowest in the groups treated with F16BP, as was the incidence of bacterial translocation. Conclusions. This study shows a protective effect of exogenous F16BP added to University of Wisconsin solution during experimental intestinal transplantation in rats. This protective effect, reflected by decreased intestinal damage and bacterial translocation, was related to a decrease in adenosine triphosphate depletion during cold ischemia before intestinal transplantation, and to the reduced availability of xanthine oxidase substrates for free radical generation during reperfusion.
Publisher version (URL)http://dx.doi.org/10.1016/j.surg.2003.10.016
URIhttp://hdl.handle.net/10261/116498
DOI10.1016/j.surg.2003.10.016
Identifiersdoi: 10.1016/j.surg.2003.10.016
issn: 0039-6060
Appears in Collections:(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.