English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/116497
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Nucleotides modulate renal ischaemia-reperfusion injury by different effects on nitric oxide and superoxide

AutorLópez-Marti, Jesús; Solà, Anna M. ; Pi, Felip ; Alfaro, Vicente; Marco, Aliceanne; Hotter, Georgina
Palabras claveRenal function
Ischaemia-reperfusion
Adenosine
Xanthine
Nitric oxide
Fecha de publicación7-abr-2003
EditorBlackwell Publishing
CitaciónClinical and Experimental Pharmacology and Physiology 30(4): 242-248 (2003)
Resumen1. The present study investigated the effects of kidney ischaemia duration on nitric oxide (NO) and superoxide (O2 -) generation at reperfusion and the role of xanthine and adenosine as mediators of NO/O2 - generation. 2. The effect of the duration of ischaemia on renal nucleotide levels was studied in two ischaemic groups (10 and 30 min). The role of adenosine and xanthine was studied in ischaemic-reperfused groups (subjected to 10 and 30 min ischaemia and 60 min reperfusion). 3. Tissue levels of adenosine decreased significantly after 30 min ischaemia, whereas xanthine/hypoxanthine levels increased concomitantly with renal dysfunction and histological damage. 4. Nitric oxide production increased significantly after 10 min ischaemia and 60 min reperfusion, whereas lipoperoxidation increased significantly after 30 min ischaemia and 60 min reperfusion. The administration of theophylline (40 mg/kg, i.p.) reversed the early increase in NO production. 5. Xanthine supplementation decreased renal function and increased lipoperoxidation. 6. In conclusion, NO/O2 - production and the subsequent renal injury/dysfunction may be modified by changes in the adenosine and xanthine levels of the injured kidney, although the present data show a significant in vivo role only for xanthine.
Versión del editorhttp://dx.doi.org/10.1046/j.1440-1681.2003.03821.x
URIhttp://hdl.handle.net/10261/116497
DOI10.1046/j.1440-1681.2003.03821.x
Identificadoresdoi: 10.1046/j.1440-1681.2003.03821.x
issn: 0305-1870
Aparece en las colecciones: (IIBB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.