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Título

Mitochondrial NOS upregulation during renal I/R causes apoptosis in a peroxynitrite-dependent manner

AutorViñas, Jose Luis ; Solà, Anna M. ; Hotter, Georgina
Palabras claveApoptosis
Peroxynitrite
Ischemia-reperfusion
Mitochondria
Cytochrome c release
Fecha de publicaciónabr-2006
EditorBlackwell Publishing
CitaciónKidney International 69(8): 1403-1409 (2006)
ResumenIn the last decade, various groups have found evidence of nitric oxide production by mitochondrial nitric oxide synthase (mNOS) in a range of experimental models. However, little is known about the role of mNOS in renal ischemia-reperfusion (I/R) injury and its possible involvement in the apoptotic pathway. We analyzed the role of mNOS in apoptosis promotion in rat kidney I/R and its direct implication through experiments in which isolated kidney mitochondria were subjected to hypoxia/reoxygenation. Results showed that neuronal NOS located in the inner mitochondrial membrane is upregulated during renal I/R and that this upregulation, together with the increase in nitric oxide production, is involved in the generation of intramitochondrial peroxynitrite, which in turn leads to cytochrome c release and apoptosis induction in renal I/R. © 2006 International Society of Nephrology.
Versión del editorhttp://dx.doi.org/10.1038/sj.ki.5000361
URIhttp://hdl.handle.net/10261/116494
DOI10.1038/sj.ki.5000361
Identificadoresdoi: 10.1038/sj.ki.5000361
issn: 0085-2538
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