Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/116362
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Emerging, non-PCV13 serotypes 11A and 35B of streptococcus pneumoniae show high potential for biofilm formation in vitro |
Autor: | Domenech, Mirian CSIC ORCID; Damián, Diana; Ardanuy, Carmen; Liñares, Josefina; Fenoll, Asunción; García, Ernesto CSIC ORCID | Fecha de publicación: | 30-abr-2015 | Editor: | Public Library of Science | Citación: | PLoS ONE 10(4): e0125636. | Resumen: | Background Since the use of pneumococcal conjugate vaccines PCV7 and PCV13 in children became widespread, invasive pneumococcal disease (IPD) has dramatically decreased. Nevertheless, there has been a rise in incidence of Streptococcus pneumoniae non-vaccine serotypes (NVT) colonising the human nasopharynx. Nasopharyngeal colonisation, an essential step in the development of S. pneumoniae-induced IPD, is associated with biofilm formation. Although the capsule is the main pneumococcal virulence factor, the formation of pneumococcal biofilms might, in fact, be limited by the presence of capsular polysaccharide (CPS). Methodology/Principal Findings We used clinical isolates of 16 emerging, non-PCV13 serotypes as well as isogenic transformants of the same serotypes. The biofilm formation capacity of isogenic transformants expressing CPSs from NVT was evaluated in vitro to ascertain whether this trait can be used to predict the emergence of NVT. Fourteen out of 16 NVT analysed were not good biofilm formers, presumably because of the presence of CPS. In contrast, serotypes 11A and 35B formed ≥45% of the biofilm produced by the non-encapsulated M11 strain. Conclusions/Significance This study suggest that emerging, NVT serotypes 11A and 35B deserve a close surveillance. | Descripción: | 11 p.-3 fig.-1 tab. | Versión del editor: | http://dx.doi.org/ 10.1371/journal.pone.0125636 | URI: | http://hdl.handle.net/10261/116362 | DOI: | 10.1371/journal.pone.0125636 | ISSN: | 1932-6203 | E-ISSN: | 1932-6203 |
Aparece en las colecciones: | (CIB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
PLOS_ONE_Domenech_2015.pdf | 791,89 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
18
checked on 17-abr-2024
SCOPUSTM
Citations
25
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
23
checked on 25-feb-2024
Page view(s)
345
checked on 22-abr-2024
Download(s)
237
checked on 22-abr-2024