English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/116362
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Emerging, non-PCV13 serotypes 11A and 35B of streptococcus pneumoniae show high potential for biofilm formation in vitro

AuthorsDomenech, Mirian ; Damián, Diana; Ardanuy, Carmen; Liñares, Josefina; Fenoll, Asunción; García, Ernesto
Issue Date30-Apr-2015
PublisherPublic Library of Science
CitationPLoS ONE 10(4): e0125636.
AbstractBackground Since the use of pneumococcal conjugate vaccines PCV7 and PCV13 in children became widespread, invasive pneumococcal disease (IPD) has dramatically decreased. Nevertheless, there has been a rise in incidence of Streptococcus pneumoniae non-vaccine serotypes (NVT) colonising the human nasopharynx. Nasopharyngeal colonisation, an essential step in the development of S. pneumoniae-induced IPD, is associated with biofilm formation. Although the capsule is the main pneumococcal virulence factor, the formation of pneumococcal biofilms might, in fact, be limited by the presence of capsular polysaccharide (CPS). Methodology/Principal Findings We used clinical isolates of 16 emerging, non-PCV13 serotypes as well as isogenic transformants of the same serotypes. The biofilm formation capacity of isogenic transformants expressing CPSs from NVT was evaluated in vitro to ascertain whether this trait can be used to predict the emergence of NVT. Fourteen out of 16 NVT analysed were not good biofilm formers, presumably because of the presence of CPS. In contrast, serotypes 11A and 35B formed ≥45% of the biofilm produced by the non-encapsulated M11 strain. Conclusions/Significance This study suggest that emerging, NVT serotypes 11A and 35B deserve a close surveillance.
Description11 p.-3 fig.-1 tab.
Publisher version (URL)http://dx.doi.org/ 10.1371/journal.pone.0125636
URIhttp://hdl.handle.net/10261/116362
DOI10.1371/journal.pone.0125636
ISSN1932-6203
E-ISSN1932-6203
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
PLOS_ONE_Domenech_2015.pdf791,89 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.