English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/116344
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


The fission yeast Greatwall-ENSA(ARPP19)-PP2A pathway links the nutritional environment to mitotic entry

AuthorsChica, Nathalia ; Pérez-Hidalgo, Livia ; Botet, Javier ; Rozalén, Ana E. ; Rubio-Tenor, Angela ; Moreno, Sergio
Issue Date2013
CitationPombe 2013
AbstractEntry into mitosis in fission yeast requires the activity of the Cdc2/Cdc13 cyclin complex. The Wee1/Cdc25 switch ensures proper timing of mitotic entry by regulating Cdc2 activity. In addition to Cdc2/Cdc13, an opposing phosphatase might contribute to the switch. According to other biological models, a suitable candidate is the protein phosphatase type 2A (PP2A) that dephosphorylates Cdk1 substrates, including Cdc25 and Wee1. Using a genome wide synthetic lethal screening with wee1-50 and cdc2-3w, we have identified one of the catalytic subunits of PP2A, Ppa2, and some of its activators (Ypa1 and Ypa2). Further dissection of this pathway, including the fission yeast orthologues of Greatwall and ENSA-ARPP19 (Ppk18 and Igo1), suggests that this pathway connects the nutritional environment (in particular nitrogen) to the mitotic switch. We will present evidence that Ppk18-Igo1-PP2A may connect TOR signalling to the mitotic switch.
DescriptionResumen del trabajo presentado a la EMBO Conference on Fission Yeast: Pombe 2013; 7th International Fission Yeast Meeting celebrada en Londres (UK) del 24 al 29 de junio de 2013.
Appears in Collections:(IBFG) Comunicaciones congresos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.