Mecanismos de regulación de la glucolisis en neuronas y su función en supervivencia celular

Abstract

This thesis described a sensitive and specific method for the determination of metabolic fluxes via the pentose phosphate and glycolysis in neurons adhered to the plate. Moreover, we identified a new molecular mechanism involved in excitotoxic neuronal death, and involves alterations in glucose metabolism mediated neuronal stabilization PFKFB3. Finally, we show that TIGAR is expressed in neurons and astrocytes , as well as having important roles in survival neuronal . In our opinion, these enzymes involved in metabolism could be of great importance as therapeutic targets in neurodegenerative diseases and pathological processes present an excitotoxic component.