Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/116263
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Zinc acquisition: A key aspect in Aspergillus fumigatus virulence |
Autor: | Amich, Jorge CSIC ORCID; Calera, José Antonio CSIC ORCID | Palabras clave: | Virulence Zinc Aspergillus |
Fecha de publicación: | 2014 | Editor: | Springer Nature | Citación: | Mycopathologia 178(5-6): 379-385 (2014) | Resumen: | Zinc is an essential micronutrient required for the growth of all microorganisms. To grow in the lungs of a susceptible patient Aspergillus fumigatus must obtain zinc from the surrounding tissues. The concentration of Zn2+ ions in living tissues is much lower than that required for optimal fungal growth in vitro because most of them are tightly bound to proteins at the physiological pH. However, A. fumigatus has several zinc transporters (ZrfA, ZrfB and ZrfC) that enable it to uptake zinc efficiently under the extreme zinc-limiting conditions provided by a susceptible host. The ZafA transcriptional regulator induces the expression of these transporters and is essential for virulence. ZrfC is required for fungal growth within the host tissues, whereas ZrfA and ZrfB play an accessory role. The zinc-scavenging capacity of ZrfC relies on its unusually long N-terminus. In addition, ZrfC also enables A. fumigatus to overcome the inhibitory effect of calprotectin, which is an antimicrobial Zn/Mn-chelating protein synthesized in high amounts by neutrophils, even in immunosuppressed non-leucopenic animals. In summary, the regulation of zinc homeostasis and zinc acquisition could be promising targets for the discovery and development of a new generation of antifungals for the treatment of invasive pulmonary aspergillosis. | URI: | http://hdl.handle.net/10261/116263 | DOI: | 10.1007/s11046-014-9764-2 | Identificadores: | doi: 10.1007/s11046-014-9764-2 issn: 0301-486X e-issn: 1573-0832 |
Aparece en las colecciones: | (IBFG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
42
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
38
checked on 15-feb-2024
Page view(s)
284
checked on 23-abr-2024
Download(s)
96
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.