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http://hdl.handle.net/10261/11588
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Sunyer, Jordi | - |
dc.contributor.author | Torrent, Maties | - |
dc.contributor.author | García-Esteban, Raquel | - |
dc.contributor.author | Ribas-Fitó, Núria | - |
dc.contributor.author | Carrizo, Daniel | - |
dc.contributor.author | Romieu, I. | - |
dc.contributor.author | Antó, Josep M. | - |
dc.contributor.author | Grimalt, Joan O. | - |
dc.date.accessioned | 2009-03-13T13:13:35Z | - |
dc.date.available | 2009-03-13T13:13:35Z | - |
dc.date.issued | 2006-10-02 | - |
dc.identifier.citation | Clinical & Experimental Allergy 36(10): 1236-1241 (2006) | en_US |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.uri | http://hdl.handle.net/10261/11588 | - |
dc.description | 6 pages, 1 figures, 3 tables.-- PMID: 17014430 [PubMed]. | en_US |
dc.description.abstract | [Objectives] Our aims were to assess association of dichlorodiphenyldichloroethylene (DDE) with childhood asthma measured up to age 6 and the effect of DDE on the protective effect of breastfeeding on asthma. In addition, we attempted to assess the relevant time-window of DDE exposure (i.e. at birth or at 4 years). | en_US |
dc.description.abstract | [Methods] All women presenting for antenatal care in Menorca, Spain over a 12-month period beginning in mid-1997 were invited to take part in a longitudinal study that included a yearly visit. Four hundred eighty-two children were enrolled and 462 provided complete outcome data after 6.5 years of follow-up. Organochlorine compounds were measured in cord serum of 402 (83%) infants and in blood samples of 285 children aged 4. We defined asthma as the presence of wheezing at age 6 and during any preceding year or doctor-diagnosed asthma, and used skin prick test at age 6 to determine atopic status. | - |
dc.description.abstract | [Results] At birth and 4 years of age, all children had detectable levels of DDE (median 1 ng/mL and 0.8 ng/mL, respectively). From birth to age 4, the mean DDE level among children with artificial feeding decreased by 72%, while among breastfed children it increased by 53%. Diagnosed asthma and persistent wheezing were associated with DDE at birth [odds ratio (OR) for an increase in 1 ng/mL, OR= 1.18, 95% confidence interval (95% CI) = 1.01-1.39 and OR 1.13, 95% CI= 0.98-1.30, respectively], but not with DDE at 4 years. Neither breastfeeding nor atopy modified these associations (P > 0.3). Breastfeeding protected against diagnosed asthma (OR = 0.33, 95% CI = 0.08-0.87) and wheezing (OR = 0.53, 95% CI = 0.34-0.82) in children with low and high DDE levels at birth. | - |
dc.description.abstract | [Conclusion] In a community without known dichlorodiphenyltrichloroethane environmental releases, this study strengthens the evidence for an effect of DDE on asthma by measuring the disease at age 6 and does not support the hypothesis that DDE modifies the protective effect of breastfeeding on asthma. | - |
dc.description.sponsorship | Funding: 'Instituto de Salud Carlos III' Red de Grupos INMA (G03/176) and 'Instituto de Salud Carlos III, Red de Centros RCESP (C03/09)'. To Maria Mirabelli and Gemma Perelló for editorial support and the participants (parents and children) for their altruism. Also to the families in the cohort for their altruism. | en_US |
dc.format.extent | 162 bytes | - |
dc.format.mimetype | application/msword | - |
dc.language.iso | eng | en_US |
dc.publisher | Blackwell Publishing | en_US |
dc.rights | closedAccess | en_US |
dc.subject | Asthma | en_US |
dc.subject | Breastfeeding | en_US |
dc.subject | Childhood | en_US |
dc.subject | DDE | en_US |
dc.subject | Exposure | en_US |
dc.title | Early exposure to dichlorodiphenyldichloroethylene, breastfeeding and asthma at age six | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1111/j.1365-2222.2006.02560.x | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1111/j.1365-2222.2006.02560.x | en_US |
dc.identifier.e-issn | 1365-2222 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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