English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/11588
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Early exposure to dichlorodiphenyldichloroethylene, breastfeeding and asthma at age six

AutorSunyer, Jordi; Torrent, Maties; Garcia-Esteban, R.; Ribas-Fitó, Núria; Carrizo, Daniel; Romieu, I.; Antó, Josep M.; Grimalt, Joan O.
Palabras claveAsthma
Fecha de publicación2-oct-2006
EditorBlackwell Publishing
CitaciónClinical & Experimental Allergy 36(10): 1236-1241 (2006)
Resumen[Objectives] Our aims were to assess association of dichlorodiphenyldichloroethylene (DDE) with childhood asthma measured up to age 6 and the effect of DDE on the protective effect of breastfeeding on asthma. In addition, we attempted to assess the relevant time-window of DDE exposure (i.e. at birth or at 4 years).
[Methods] All women presenting for antenatal care in Menorca, Spain over a 12-month period beginning in mid-1997 were invited to take part in a longitudinal study that included a yearly visit. Four hundred eighty-two children were enrolled and 462 provided complete outcome data after 6.5 years of follow-up. Organochlorine compounds were measured in cord serum of 402 (83%) infants and in blood samples of 285 children aged 4. We defined asthma as the presence of wheezing at age 6 and during any preceding year or doctor-diagnosed asthma, and used skin prick test at age 6 to determine atopic status.
[Results] At birth and 4 years of age, all children had detectable levels of DDE (median 1 ng/mL and 0.8 ng/mL, respectively). From birth to age 4, the mean DDE level among children with artificial feeding decreased by 72%, while among breastfed children it increased by 53%. Diagnosed asthma and persistent wheezing were associated with DDE at birth [odds ratio (OR) for an increase in 1 ng/mL, OR= 1.18, 95% confidence interval (95% CI) = 1.01-1.39 and OR 1.13, 95% CI= 0.98-1.30, respectively], but not with DDE at 4 years. Neither breastfeeding nor atopy modified these associations (P > 0.3). Breastfeeding protected against diagnosed asthma (OR = 0.33, 95% CI = 0.08-0.87) and wheezing (OR = 0.53, 95% CI = 0.34-0.82) in children with low and high DDE levels at birth.
[Conclusion] In a community without known dichlorodiphenyltrichloroethane environmental releases, this study strengthens the evidence for an effect of DDE on asthma by measuring the disease at age 6 and does not support the hypothesis that DDE modifies the protective effect of breastfeeding on asthma.
Descripción6 pages, 1 figures, 3 tables.-- PMID: 17014430 [PubMed].
Versión del editorhttp://dx.doi.org/10.1111/j.1365-2222.2006.02560.x
Aparece en las colecciones: (IDAEA) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.