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Rescue of the streptomycin antibiotic activity by using streptidine as a "decoy acceptor" for the aminoglycoside-inactivating enzyme adenyl transferase

AuthorsLatorre, Montserrat; Penalver, Pablo; Revuelta, Julia ; Asensio, Juan Luis ; García-Junceda, Eduardo ; Bastida, Agatha
Keywordsdecoy acceptor
antibiotic activity
Issue Date2007
PublisherRoyal Society of Chemistry (UK)
CitationChemical Communications 2007, 2829-2831.
AbstractIn this work, we show that the streptidine moiety of streptomycin is substrate for the aminoglycoside inactivating enzyme ANT(6). The addition of this molecule in cell culture restores the activity of the streptomycin antibiotic normally inactivated by the ANT(6) enzyme, because the streptidine competes with the streptomycin acting as a decoy acceptor of the ANT(6). Thus, streptidine could be a good starting compound for the design of more efficient decoy acceptors of aminoglycoside-modifying enzymes.
Publisher version (URL)http://www.rsc.org/delivery/_ArticleLinking/ArticleLinking.asp?JournalCode=CC&Year=2007&ManuscriptID=b704785a&Iss=27
Appears in Collections:(IQOG) Artículos
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