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Título

Rescue of the streptomycin antibiotic activity by using streptidine as a "decoy acceptor" for the aminoglycoside-inactivating enzyme adenyl transferase

AutorLatorre, Montserrat; Penalver, Pablo; Revuelta, Julia ; Asensio, Juan Luis ; García-Junceda, Eduardo ; Bastida, Agatha
Palabras clavedecoy acceptor
streptomycin
antibiotic activity
aminoglycoside
Fecha de publicación2007
EditorRoyal Society of Chemistry (Great Britain)
CitaciónChemical Communications 2007, 2829-2831.
ResumenIn this work, we show that the streptidine moiety of streptomycin is substrate for the aminoglycoside inactivating enzyme ANT(6). The addition of this molecule in cell culture restores the activity of the streptomycin antibiotic normally inactivated by the ANT(6) enzyme, because the streptidine competes with the streptomycin acting as a decoy acceptor of the ANT(6). Thus, streptidine could be a good starting compound for the design of more efficient decoy acceptors of aminoglycoside-modifying enzymes.
Versión del editorhttp://www.rsc.org/delivery/_ArticleLinking/ArticleLinking.asp?JournalCode=CC&Year=2007&ManuscriptID=b704785a&Iss=27
URIhttp://hdl.handle.net/10261/11587
DOI10.1039/b704785a
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