English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/115761
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Clustering effects on postprandial insulin secretion and sensitivity in response to meals with different fatty acid compositions

AutorBermúdez, Beatriz ; Ortega, Almudena ; Varela, Lourdes; Villar, José; Abia, Rocío ; Muriana, Francisco J. G. ; López, Sergio
Palabras claveFatty acids
β-cell function
Insulin sensitivity
Postprandial state
Fecha de publicación17-mar-2014
EditorRoyal Society of Chemistry (Great Britain)
CitaciónFood Funct., 5: 1374-1380 (2014)
ResumenDietary fatty acids play a role in glucose homeostasis. The aim of this study was to assess the individual relationship between dietary saturated (SFA), monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids with postprandial β-cell function and insulin sensitivity in subjects with normal and high fasting triglycerides. We assessed postprandial β-cell function (by the insulinogenic index and the ratio of the insulin to glucose areas under the time–concentration curve) and insulin sensitivity (by the oral glucose and the minimal model insulin sensitivity indices) over four nonconsecutive, randomly assigned, high-fat meals containing a panel of SFA (palmitic and stearic acids), MUFA (palmitoleic and oleic acids) and PUFA (linoleic and α-linolenic acids) in 14 subjects with normal and in 14 subjects with high fasting triglycerides. The proportions of each fatty acid in the meals and the values for surrogate measures of postprandial β-cell function and insulin sensitivity were subjected to a Pearson correlation and hierarchical cluster analysis, which revealed two classes of dietary fatty acids for regulating postprandial glucose homeostasis. We successfully discriminated the adverse effects of SFA palmitic acid from the beneficial effects of MUFA oleic acid on postprandial β-cell function (r ≥ 0.84 for SFA palmitic acid and r ≥ −0.71 for MUFA oleic acid; P < 0.05) and insulin sensitivity (r ≥ −0.92 for SFA palmitic acid and r ≥ 0.89 for MUFA oleic acid; P < 0.001) both in subjects with normal and high fasting triglycerides. In conclusion, dietary MUFA oleic acid, in contrast to SFA palmitic acid, favours the tuning towards better postprandial glycaemic control in subjects with normal and high fasting triglycerides.
Descripción22 páginas
Versión del editorhttp://dx.doi.org/10.1039/C4FO00067F
URIhttp://hdl.handle.net/10261/115761
DOI10.1039/C4FO00067F
ISSN2042-6496
E-ISSN2042-650X
Aparece en las colecciones: (IG) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Postprint_Food_Funct_2014_1374.pdf529,59 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.