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Título

Worldwide genetic variation at the 3′ untranslated region of the HLA-G gene: balancing selection influencing genetic diversity

Autor Sabbagh, Audrey; Luisi, Pierre ; Laayouni, Hafid
Palabras clave HLA-G
3′UTR
Haplotype
Linkage disequilibrium
Balancing selection
Evolution
Fecha de publicación 2014
EditorNature Publishing Group
Citación Genes and Immunity 15: 95-106 (2014)
ResumenThe HLA-G (human leukocyte antigen-G) molecule plays a pivotal role in immune tolerance by inhibiting different cell subsets involved in both innate and adaptive immunity. Besides its primary function in maintaining the maternal–fetal tolerance, HLA-G has been involved in a wide range of pathological conditions where it can be either favorable or detrimental to the patient, depending on the nature of the pathology. Although several studies have demonstrated the utmost importance of the 3′ untranslated region (3′UTR) in the HLA-G expression profile, limited data exist on the sequence variability of this gene region in human populations. In this study, we characterized the genetic diversity and haplotype structure of the HLA-G 3′UTR by resequencing 444 individuals from three sub-Saharan African populations and retrieving data from the 1000 Genomes project and the literature. A total of 1936 individuals representing 21 worldwide populations were combined and jointly analyzed. Our data revealed a high level of nucleotide diversity, an excess of intermediate frequency variants and an extremely low population differentiation, strongly supporting a history of balancing selection at this locus. The 14-bp insertion/deletion polymorphism was further pointed out as the likely target of selection, emphasizing its potential role in the post-transcriptional regulation of HLA-G expression.
Descripción Sabbagh, Audrey et al.
Versión del editorhttp://dx.doi.org/10.1038/gene.2013.67
URI http://hdl.handle.net/10261/115754
DOI10.1038/gene.2013.67
ISSN1466-4879
1476-5470
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