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The common marmoset genome provides insight into primate biology and evolution

AutorWorley, Kim C.; Lorente-Galdós, Belén ; Marqués-Bonet, Tomàs ; Wilson, Richard K.
Fecha de publicación2014
EditorNature Publishing Group
CitaciónNature Genetics 46: 850-857 (2014)
ResumenWe report the whole-genome sequence of the common marmoset (Callithrix jacchus). The 2.26-Gb genome of a female marmoset was assembled using Sanger read data (6×) and a whole-genome shotgun strategy. A first analysis has permitted comparison with the genomes of apes and Old World monkeys and the identification of specific features that might contribute to the unique biology of this diminutive primate, including genetic changes that may influence body size, frequent twinning and chimerism. We observed positive selection in growth hormone/insulin-like growth factor genes (growth pathways), respiratory complex I genes (metabolic pathways), and genes encoding immunobiological factors and proteases (reproductive and immunity pathways). In addition, both protein-coding and microRNA genes related to reproduction exhibited evidence of rapid sequence evolution. This genome sequence for a New World monkey enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application. © 2014 Nature America, Inc.
DescripciónThe Marmoset Genome Sequencing and Analysis Consortium.-- Worley, Kim C. et al.
Versión del editorhttp://dx.doi.org/10.1038/ng.3042
Identificadoresdoi: 10.1038/ng.3042
e-issn: 1546-1718
issn: 1061-4036
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