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Specification of differentiated adult progenitors via inhibition of endocycle entry in the Drosophila trachea

AutorDjabrayan, Nareg J.-V.; Cruz, Josefa ; Miguel, Cristina de ; Franch-Marro, Xavier ; Casanova, Jordi
Fecha de publicaciónnov-2014
CitaciónCell Reports 9(3): 859-865 (2014)
ResumenA population of Drosophila adult tracheal progenitor cells arises from differentiated cells of the larval main trachea that retain the ability to reenter the cell cycle and give rise to the multiple adult tracheal cell types. These progenitors are unique to the second tracheal metamere as homologous cells from other segments, express fizzy-related (fzr), the Drosophila homolog of CDH1 protein of the APC complex, and enter endocycle and do not contribute to adult trachea. Here, we examine the mechanisms for their quiescence and show that they reenter the cell cycle by expression of string/cdc25 through ecdysone. Furthermore, we show that preventing endocycle entry is both necessary and sufficient for these tracheal cells to exhibit markers of adult progenitors, thus modifying their genetic program. Finally, we show that Hox-mediated regulation of fzr expression is responsible for progenitor identity and thus specifies a group of differentiated cells with facultative stem cell features. © 2014 The Authors.
DescripciónUnder a Creative Commons license
Versión del editorhttp://dx.doi.org/10.1016/j.celrep.2014.09.043
Identificadoresdoi: 10.1016/j.celrep.2014.09.043
issn: 2211-1247
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