English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/115682
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Characterization of hepatitis E virus recombinant ORF2 proteins expressed by vaccinia viruses

AuthorsJiménez de Oya, Nereida; Escribano-Romero, Estela; Blázquez, Ana Belén; Lorenzo, María; Martín-Acebes, Miguel Ángel; Blasco, Rafael; Saiz, Juan Carlos
Issue Date2012
PublisherAmerican Society for Microbiology
CitationJournal of Virology 86 (15): 7880-7886 (2012)
AbstractHepatitis E virus (HEV), an enterically transmitted pathogen, is one of the major causes of acute hepatitis in humans worldwide, being responsible for outbreaks and epidemics in regions with suboptimal sanitary conditions, in many of which it is endemic. In industrialized countries, hepatitis E is rarely reported, but recent studies have revealed quite high human seroprevalence rates and the possibility of porcine zoonotic transmission. There is currently no specific therapy or licensed vaccine against HEV infection, and little is known about its intracellular growth cycle, as until very recently no efficient cell culture system has been available. In the present study, vaccinia viruses have been used to express recombinant HEV ORF2 proteins, allowing the study of their glycosylation patterns and subcellular localization. Furthermore, the expressed proteins have been shown to be good antigens for diagnostic purposes and to elicit high and long-lasting specific anti-HEV titers of antibodies in mice that are passively transferred to the offspring by both transplacental and lactation routes.
URIhttp://hdl.handle.net/10261/115682
DOIhttp://dx.doi.org/10.1128/JVI.00610-12
Identifiersdoi: 10.1128/JVI.00610-12
issn: 0022-538X
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
MA_Martin_Acebes_Charaterization_Hepatitis_E_Virus.pdf1,31 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.