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http://hdl.handle.net/10261/115655
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Delgado-Esteban, María | - |
dc.contributor.author | García-Higuera, Irene | - |
dc.contributor.author | Maestre, Carolina | - |
dc.contributor.author | Moreno, Sergio | - |
dc.contributor.author | Almeida, Angeles | - |
dc.date.accessioned | 2015-05-22T11:28:10Z | - |
dc.date.available | 2015-05-22T11:28:10Z | - |
dc.date.issued | 2013 | - |
dc.identifier | e-issn: 2041-1723 | - |
dc.identifier.citation | Nature Communications 4: 2879 (2013) | - |
dc.identifier.uri | http://hdl.handle.net/10261/115655 | - |
dc.description.abstract | The morphology of the adult brain is the result of a delicate balance between neural progenitor proliferation and the initiation of neurogenesis in the embryonic period. Here we assessed whether the anaphase-promoting complex/cyclosome (APC/C) cofactor, Cdh1 - which regulates mitosis exit and G1-phase length in dividing cells - regulates neurogenesis in vivo. We use an embryo-restricted Cdh1 knockout mouse model and show that functional APC/C-Cdh1 ubiquitin ligase activity is required for both terminal differentiation of cortical neurons in vitro and neurogenesis in vivo. Further, genetic ablation of Cdh1 impairs the ability of APC/C to promote neurogenesis by delaying the exit of the progenitor cells from the cell cycle. This causes replicative stress and p53-mediated apoptotic death resulting in decreased number of cortical neurons and cortex size. These results demonstrate that APC/C-Cdh1 coordinates cortical neurogenesis and size, thus posing Cdh1 in the molecular pathogenesis of congenital neurodevelopmental disorders, such as microcephaly. © 2013 Macmillan Publishers Limited. | - |
dc.description.sponsorship | This work was funded by Instituto de Salud Carlos III (PS09/0366, PI12/0685; RD06/0026/1008), FEDER (European regional development fund), Ministerio de Economía y Competitividad (BFU2011-28274, CSD2007-00015) and Junta de Castilla y León (CSI240A12-1). I.G.-H. is supported by Fundación Científica de la Asociación Española contra el Cáncer (AECC). M.D.-E. is supported by Instituto de Salud Carlos III (RD12/0014/0007). | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | closedAccess | - |
dc.title | APC/C-Cdh1 coordinates neurogenesis and cortical size during development | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1038/ncomms3879 | - |
dc.date.updated | 2015-05-22T11:28:10Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Junta de Castilla y León | - |
dc.contributor.funder | Fundación Científica Asociación Española Contra el Cáncer | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002704 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100014180 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
Aparece en las colecciones: | (IBFG) Artículos (IBMCC) Artículos |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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