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Title: | APC/C-Cdh1 coordinates neurogenesis and cortical size during development |
Authors: | Delgado-Esteban, María ![]() ![]() ![]() ![]() |
Issue Date: | 2013 |
Publisher: | Nature Publishing Group |
Citation: | Nature Communications 4: 2879 (2013) |
Abstract: | The morphology of the adult brain is the result of a delicate balance between neural progenitor proliferation and the initiation of neurogenesis in the embryonic period. Here we assessed whether the anaphase-promoting complex/cyclosome (APC/C) cofactor, Cdh1 - which regulates mitosis exit and G1-phase length in dividing cells - regulates neurogenesis in vivo. We use an embryo-restricted Cdh1 knockout mouse model and show that functional APC/C-Cdh1 ubiquitin ligase activity is required for both terminal differentiation of cortical neurons in vitro and neurogenesis in vivo. Further, genetic ablation of Cdh1 impairs the ability of APC/C to promote neurogenesis by delaying the exit of the progenitor cells from the cell cycle. This causes replicative stress and p53-mediated apoptotic death resulting in decreased number of cortical neurons and cortex size. These results demonstrate that APC/C-Cdh1 coordinates cortical neurogenesis and size, thus posing Cdh1 in the molecular pathogenesis of congenital neurodevelopmental disorders, such as microcephaly. © 2013 Macmillan Publishers Limited. |
URI: | http://hdl.handle.net/10261/115655 |
DOI: | http://dx.doi.org/10.1038/ncomms3879 |
Identifiers: | e-issn: 2041-1723 |
Appears in Collections: | (IBFG) Artículos (IBMCC) Artículos |
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