English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/115587
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 45 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

Regulated aggregative multicellularity in a close unicellular relative of metazoa

Autor Sebé-Pedrós, Arnau ; Irimia, Manuel; Campo, Javier del ; Parra-Acero, Helena ; Russ, Carsten; Nusbaum, Chad; Blencowe, Benjamin J.; Ruiz-Trillo, Iñaki
Fecha de publicación 24-dic-2013
EditoreLife Sciences Publications
Citación eLife 2: e01287 (2013)
ResumenThe evolution of metazoans from their unicellular ancestors was one of the most important events in the history of life. However, the cellular and genetic changes that ultimately led to the evolution of multicellularity are not known. In this study, we describe an aggregative multicellular stage in the protist Capsaspora owczarzaki, a close unicellular relative of metazoans. Remarkably, transition to the aggregative stage is associated with significant upregulation of orthologs of genes known to establish multicellularity and tissue architecture in metazoans. We further observe transitions in regulated alternative splicing during the C. owczarzaki life cycle, including the deployment of an exon network associated with signaling, a feature of splicing regulation so far only observed in metazoans. Our results reveal the existence of a highly regulated aggregative stage in C. owczarzaki and further suggest that features of aggregative behavior in an ancestral protist may had been co-opted to develop some multicellular properties currently seen in metazoans. © Sebé-Pedrós et al.
Versión del editorhttp://dx.doi.org/10.7554/eLife.01287
URI http://hdl.handle.net/10261/115587
DOI10.7554/eLife.01287
Identificadoresdoi: 10.7554/eLife.01287
issn: 2050-084X
Aparece en las colecciones: (IBE) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
aggregative_multicellularity_Sebe.pdf5,15 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.