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dc.contributor.authorSebé-Pedrós, Arnau-
dc.contributor.authorZheng, Yonggang-
dc.contributor.authorRuiz-Trillo, Iñaki-
dc.contributor.authorPan, Duojia-
dc.date.accessioned2015-05-21T07:44:21Z-
dc.date.available2015-05-21T07:44:21Z-
dc.date.issued2012-01-26-
dc.identifierdoi: 10.1016/j.celrep.2011.11.004-
dc.identifierissn: 2211-1247-
dc.identifier.citationCell Reports 1(1): 13-20 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/115532-
dc.description.abstractNonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of the Hippo pathway in nonbilaterian animals, but failed to identify this pathway outside Metazoa. Through comparative analyses of recently sequenced holozoan genomes, we show that Hippo pathway components, such as the kinases Hippo and Warts, the coactivator Yorkie, and the transcription factor Scalloped, were already present in the unicellular ancestors of animals. Remarkably, functional analysis of Hippo components of the amoeboid holozoan Capsaspora owczarzaki, performed in Drosophila melanogaster, demonstrate that the growth-regulatory activity of the Hippo pathway is conserved in this unicellular lineage. Our findings show that the Hippo pathway evolved well before the origin of Metazoa and highlight the importance of Hippo signaling as a key developmental mechanism predating the origin of Metazoa. © 2012 The Authors.-
dc.description.sponsorshipThis work was supported by an Institució Catalana per a la Recerca i Estudis Avançats contract, a European Research Council Starting Grant (ERC-2007-StG-206883), a grant (BFU2008-02839/BMC) from Ministerio de Ciencia e Innovación (MICINN) to I. R.-T., and a National Institutes of Health grant (R01 EY015708) to D.P. A.S-P. was supported by a pregraduate Formacion Profesorado Universitario grant from MICINN. D.P. is an investigator of the Howard Hughes Medical Institute.-
dc.publisherElsevier-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titlePremetazoan Origin of the Hippo Signaling Pathway-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1016/j.celrep.2011.11.004-
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.celrep.2011.11.004-
dc.date.updated2015-05-21T07:44:22Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by/3.0/-
dc.contributor.funderEuropean Research Council-
dc.contributor.funderGeneralitat de Catalunya-
dc.contributor.funderMinisterio de Ciencia e Innovación (España)-
dc.contributor.funderNational Institutes of Health (US)-
dc.contributor.funderHoward Hughes Medical Institute-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002809es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004837es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000002es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000011es_ES
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