English
español
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/115532
Share/Impact:
Statistics |
![]() ![]() ![]() |
|
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |||
|
Title: | Premetazoan Origin of the Hippo Signaling Pathway |
Authors: | Sebé-Pedrós, Arnau ![]() ![]() |
Issue Date: | 26-Jan-2012 |
Publisher: | Elsevier |
Citation: | Cell Reports 1(1): 13-20 (2012) |
Abstract: | Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of the Hippo pathway in nonbilaterian animals, but failed to identify this pathway outside Metazoa. Through comparative analyses of recently sequenced holozoan genomes, we show that Hippo pathway components, such as the kinases Hippo and Warts, the coactivator Yorkie, and the transcription factor Scalloped, were already present in the unicellular ancestors of animals. Remarkably, functional analysis of Hippo components of the amoeboid holozoan Capsaspora owczarzaki, performed in Drosophila melanogaster, demonstrate that the growth-regulatory activity of the Hippo pathway is conserved in this unicellular lineage. Our findings show that the Hippo pathway evolved well before the origin of Metazoa and highlight the importance of Hippo signaling as a key developmental mechanism predating the origin of Metazoa. © 2012 The Authors. |
Publisher version (URL): | http://dx.doi.org/10.1016/j.celrep.2011.11.004 |
URI: | http://hdl.handle.net/10261/115532 |
DOI: | http://dx.doi.org/10.1016/j.celrep.2011.11.004 |
Identifiers: | doi: 10.1016/j.celrep.2011.11.004 issn: 2211-1247 |
Appears in Collections: | (IBE) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
premetazoan_origin_Sebe.pdf | 1,1 MB | Adobe PDF | ![]() View/Open |
Show full item record
Review this work
Review this work
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.