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Title

Pogo-like transposases have been repeatedly domesticated into CENP-B-related proteins

AuthorsMateo, Lidia ; González Pérez, Josefa
KeywordsPogo
Drosophila
Exaptation
Functional domain
Holocentric chromosomes
Issue Date2014
PublisherOxford University Press
CitationGenome Biology and Evolution 6(8): 2008-2016 (2014)
AbstractThe centromere is a chromatin region that is required for accurate inheritance of eukaryotic chromosomes during cell divisions. Among the different centromere-associated proteins (CENP) identified, CENP-B has been independently domesticated from a pogo-like transposase twice: Once in mammals and once in fission yeast. Recently, a third independent domestication restricted to holocentric lepidoptera has been described. In this work, we take advantage of the high-quality genome sequence and the wealth of functional information available for Drosophila melanogaster to further investigate the possibility of additional independent domestications of pogo-like transposases into host CENP-B related proteins. Our results showed that CENP-B related genes are not restricted to holocentric insects. Furthermore, we showed that at least three independent domestications of pogo-like transposases have occurred in metazoans. Our results highlight the importance of transposable elements as raw material for the recurrent evolution of important cellular functions. © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
Publisher version (URL)http://dx.doi.org/10.1093/gbe/evu153
URIhttp://hdl.handle.net/10261/115499
DOI10.1093/gbe/evu153
Identifiersdoi: 10.1093/gbe/evu153
issn: 1759-6653
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