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Título

Acid-dependent viral entry

Autor Vázquez Calvo, M. Carmen ; Saiz, Juan Carlos; McCullough, Kenneth C.; Sobrino Castelló, Francisco; Martín-Acebes, Miguel Ángel
Palabras clave Membrane fusion
Uncoating
Viral internalisation
Acidic pH
Endosome
Fecha de publicación 2012
EditorElsevier
Citación Virus Research 167: 125- 137 (2012)
ResumenVirus infection of host cells requires that entry into the cell results in efficient genome release leading to translation and replication. These initial steps revolving around the entry and genomic release processes are crucial for viral progeny generation. Despite the variety of receptors used by viruses to initiate entry, evidence from both enveloped and non-enveloped viral infections is highlighting the important role played by intracellular acidic compartments in the entry of many viruses. These compartments provide connecting nodes within the endocytic network, presenting multiple viral internalization pathways. Endosomal compartments employing an internal acidic pH can trigger molecular mechanisms leading to disassembly of viral particles, thus providing appropriate genome delivery. Accordingly, viruses have evolved to select optimal intracellular conditions for promoting efficient genome release, leading to propagation of the infectious agent. This review will address the implications of cellular compartment involvement in virus infectious processes, and the roles played by the viruses' own machinery, including pH sensing mechanisms and the methodologies applied for studying acid-dependent viral entry into host cells.
URI http://hdl.handle.net/10261/115497
DOI10.1016/j.virusres.2012.05.024
Identificadoresdoi: 10.1016/j.virusres.2012.05.024
issn: 0168-1702
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