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Title

Novel roles of plant RETINOBLASTOMA-RELATED (RBR) protein in cell proliferation and asymmetric cell division

AuthorsDesvoyes, Bénédicte ; Mendoza, Alex de ; Ruiz-Trillo, Iñaki ; Gutiérrez Armenta, Crisanto
KeywordsGene expression
Cell cycle
Retinoblastoma-related (RBR).
Arabidopsis
Phosphorylation
Plant
Rb plylogenetic tree
Asymmetric cell division
Issue Date2014
PublisherOxford University Press
CitationJournal of Experimental Botany 65(10): 2657-2666 (2014)
AbstractThe retinoblastoma (Rb) protein was identified as a human tumour suppressor protein that controls various stages of cell proliferation through the interaction with members of the E2F family of transcription factors. It was originally thought to be specific to animals but plants contain homologues of Rb, called RETINOBLASTOMA-RELATED (RBR). In fact, the Rb-E2F module seems to be a very early acquisition of eukaryotes. The activity of RBR depends on phosphorylation of certain amino acid residues, which in most cases are well conserved between plant and animal proteins. In addition to its role in cell-cycle progression, RBR has been shown to participate in various cellular processes such as endoreplication, transcriptional regulation, chromatin remodelling, cell growth, stem cell biology, and differentiation. Here, we discuss the most recent advances to define the role of RBR in cell proliferation and asymmetric cell division. These and other reports clearly support the idea that RBR is used as a landing platform of a plethora of cellular proteins and complexes to control various aspects of cell physiology and plant development. © The Author 2013.
DescriptionThis article appears in:Special Issue: Plant Cell Cycle and Chromatin and Epigenetics.
Publisher version (URL)http://dx.doi.org/10.1093/jxb/ert411
URIhttp://hdl.handle.net/10261/115321
DOI10.1093/jxb/ert411
Identifiersdoi: 10.1093/jxb/ert411
e-issn: 1460-2431
issn: 0022-0957
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