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Título

Utility of CD200 immunostaining in the diagnosis of primary mediastinal large B cell Lympohoma: comparison with MAL, CD23, and other markers

Autor Dorfman, David M.; Shahsafaei, Aliakbar; Alonso, Miguel A.
Palabras clave REL
TRAF
Diffuse large B cell lymphoma
Fecha de publicación 2012
EditorNature Publishing Group
Citación Modern Pathology 25: 1637-1643 (2012)
ResumenCD200, an immunoglobulin superfamily membrane glycoprotein, is expressed in a number of B cell lymphoproliferative disorders, including primary mediastinal large B cell lymphoma, but not diffuse large B cell lymphoma, based on a preliminary study. Here, we compare the expression of CD200 with other markers of primary mediastinal large B cell lymphoma, including MAL and CD23, in formalin-fixed, paraffin-embedded histologic sections from a series of 35 cases of primary mediastinal large B cell lymphoma and 30 cases of diffuse large B cell lymphoma. CD200 exhibits the greatest staining sensitivity of the markers studied: 94%,compared with CD23 (69%), MAL (86%), TRAF (86%), and REL (77%). It exhibits staining specificity of 93%, similar to that of CD23 (93%) and MAL (97%), and greater than that of TRAF (77%) and REL (83%). We conclude that CD200 is a practical and useful marker for the diagnosis of primary mediastinal large B cell lymphoma.
URI http://hdl.handle.net/10261/115315
DOI10.1038/modpathol.2012.129
Identificadoresdoi: 10.1038/modpathol.2012.129
issn: 0893-3952
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