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Título: | Three-dimensional visualization of forming Hepatitis C virus-like particles by electron-tomography |
Autor: | Badia-Martínez, Daniel; Peralta, Bibiana; Andrés, Germán CSIC ORCID; Guerra, Milagros CSIC ORCID; Gil-Cartón, David; Abrescia, Nicola G. A. | Palabras clave: | Electron tomography Hepatitis C virus-like-particles Hepatitis C virus Budding Morphogenesis |
Fecha de publicación: | 2012 | Editor: | Academic Press | Citación: | Virology 430: 120-126 (2012) | Resumen: | Hepatitis C virus infects almost 170 million people per year but its assembly pathway, architecture and the structures of its envelope proteins are poorly understood. Using electron tomography of plastic-embedded sections of insect cells, we have visualized the morphogenesis of recombinant Hepatitis C virus-like particles. Our data provide a three-dimensional sketch of viral assembly at the endoplasmic reticulum showing different budding stages and contiguity of buds. This latter phenomenon could play an important role during the assembly of . wt-HCV and explain the size-heterogeneity of its particles. | URI: | http://hdl.handle.net/10261/115187 | DOI: | 10.1016/j.virol.2012.05.001 | Identificadores: | doi: 10.1016/j.virol.2012.05.001 issn: 0042-6822 |
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