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Title

Moderate consumption of red wine modulates intestinal inflammation response as measured in human faeces

AuthorsMuñoz-González, Irene ; Espinosa-Martos, Irene; Rodríguez, Juan M.; Martín-Álvarez, Pedro J. ; Bartolomé, Begoña ; Moreno-Arribas, M. Victoria
KeywordsHuman faeces
Inflammatory markers
Red wine
Polyphenols
Issue Date2014
CitationWAC 2014
AbstractWine polyphenols could contribute to the modulation of the intestinal inflammatory response; however, most of the molecular mechanisms related to these effects remain largely unknown. Immunoglobulins and cytokines play an important role in the modulation of the intestinal immune system. Any inflammatory marker produced locally as a result of intestinal inflammation may leak into the bowel lumen and be excreted in the stools, that makes its analysis an useful and non-invasive approach to detect and to ascertain the effect of dietary interventions on intestinal inflammation. This work aims to assess the potential of moderate red wine consumption to modulate intestinal inflammation response as measured in human faeces. For that purpose, 24 immune markers were analysed in faeces from healthy volunteers (n=34) before and after moderate consumption of polyphenols-rich red wine for 4 weeks. Samples from a control group (no wine consumption, n=8) were also analyzed. Globally, statistically significant differences were only found for the faecal content of interleukin-13 before and after wine consumption. However, a detailed exploration of the values before wine consumption indicated that a subgroup of 6 volunteers showed unusually high values for several cytokines (i.e., 120.9 - 3624 ng/g for IFN-γ). For this subgroup, statistical analysis revealed significant decreases in 16 out of 24 markers after wine consumption, which made inflammatory markers stayed at usual levels at the end of the wine intervention period. This communication provides the most complete study on modulation of the inflammatory intestinal response after moderate wine consumption.
DescriptionResumen del trabajo presentado a la Third Edition of the International Conference Series on Wine Active Compounds celebrada en Beaune (Francia) del 26 al 28 de marzo de 2014.
URIhttp://hdl.handle.net/10261/115088
Appears in Collections:(CIAL) Comunicaciones congresos
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