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Title

Combination of quercetin and kaempferol enhances in vitro cytotoxicity on human colon cancer (HCT-116) cells

AuthorsJaramillo Carmona, S. ; López, Sergio ; Abia, Rocío ; Rodríguez-Arcos, Rocío ; Jiménez Araujo, Ana ; Guillén Bejarano, Rafael ; Muriana, Francisco J. G.
KeywordsCytotoxicity
Synergy.
Colon cancer
Kaempferol
Quercetin
Issue Date2014
PublisherAcademy of Chemistry of Globe
CitationRecords of Natural Products 8: 262- 271 (2014)
AbstractColon cancer is one of the most common types of cancer malignancy. Although flavonoids naturally occur as mixtures, little information is available regarding the additive or synergistic biochemical interactions between flavonoids. The objectives of this study were to examine the feasibility of combining two major structurally related flavonoids, quercetin and kaempferol, to affect the cell viability, cell cycle, and proliferation of the human colon cancer HCT-116 cell line. The combination of quercetin and kaempferol exhibited a greater cytotoxic efficacy than did either quercetin or kaempferol alone. This effect was highest and acted in a synergistic fashion in a 2-fold quercetin and 1-fold kaempferol IC50 combination, which also arrested cell growth in the G2/M phase and suppressed proliferation. Our observations support a structure-activity relationship based on the presence of 3'-OH moiety and/or 4'-OH moiety on the B-ring of flavonoids. © 2014 ACG Publications. All rights reserved.
URIhttp://hdl.handle.net/10261/115037
Identifiersissn: 1307-6167
Appears in Collections:(IG) Artículos
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