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Title

Regular Consumption of an Antioxidant-rich Juice Improves Oxidative Status and Causes Metabolome Changes in Healthy Adults

AuthorsDíaz Rubio, M. Elena ; Pérez-Jiménez, Jara ; Martínez-Bartolomé, Miguel A. ; Álvarez Acero, Inmaculada
KeywordsOxidative status
Antioxidant capacity
Grape
Metabolomics
Fruit juice
Pomegranate
Issue Date2015
PublisherSpringer
CitationPlant Foods for Human Nutrition 70: 9-14 (2015)
AbstractAn improvement in oxidative status is associated with a reduction in the incidence of several chronic diseases. However, daily intake of antioxidants in Western diets is decreasing. This study evaluates the effect of daily consumption of an antioxidant-rich juice (ARJ) on oxidative status, cardiovascular disease risk parameters, and untargeted plasma and urine metabolomes. Twenty-eight healthy young adults participated in an 8-week clinical trial by drinking 200 mL of ARJ (pomegranate and grape) daily. At the end of the study, the subjects showed a significant decrease (−29 %) in plasma lipid oxidation (malondialdehyde concentration), and a significant increase (+115 %) in plasma antioxidant capacity. Plasma and urine metabolomes were also significantly modified and some ions modified in urine were identified, including metabolites of polyphenols, ascorbic acid and biliary acids. No significant changes were observed in lipid profile, inflammation, blood pressure or glycaemia. These results show that incorporating antioxidant-rich beverages into common diets may improve oxidative status in healthy subjects.
URIhttp://hdl.handle.net/10261/115031
DOIhttp://dx.doi.org/10.1007/s11130-014-0455-4
Identifiersdoi: 10.1007/s11130-014-0455-4
issn: 0921-9668
Appears in Collections:(ICTAN) Artículos
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