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Foodomics of dietary polyphenols effect against human cancer cell lines

AutorIbáñez, Clara ; Valdés, Alberto ; Simó, Carolina ; Herrero, Miguel ; Ibáñez, Elena ; Ferragut, José A.; García-Cañas, Virginia ; Cifuentes, Alejandro
Fecha de publicación2013
CitaciónEuroFoodChem XVII (2013)
ResumenThe present use of advanced “omics” tools in food science and nutrition allows investigating topics that were considered unapproachable few years ago, this trend has generated a new discipline defined for the first time by our group as “Foodomics”. In Foodomics, food safety, quality and bioactivity are investigated through the application of advanced omics technologies in order to improve consumers’ well-being, health and knowledge. In this work, a Foodomics strategy is applied to investigate the anti-proliferative effect of dietary polyphenols from rosemary against different human cancer cell lines. Namely, two leukemia cell models (one showing a drug-sensitive phenotype, and another exhibiting a drug-resistant phenotype) and two colon cancer lines were investigated. Whole-transcriptome microarray together with MS-based non-targeted whole-metabolome approaches were employed to carry out transcriptomics and metabolomics analyses, respectively. Functional enrichment analysis was done using Ingenuity Pathway Analysis (IPA) software as a previous step for a reliable interpretation of transcriptomic and metabolomic profiles. Integration of data obtained from transcriptomics and metabolomics platforms was done by overlaying datasets on canonical (defined) metabolic pathways using IPA software. This strategy enabled the identification of several differentially expressed genes alone and/or linked to the changed metabolic pathways that were modulated by rosemary polyphenols providing new evidences at molecular level on the effect of these compounds.
DescripciónResumen del trabajo presentado en el EuroFoodChem XVII celebrado en Istambul (Turkey) del 7 al 10 de mayo de 2013.
URIhttp://hdl.handle.net/10261/115016
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