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The bifidogenic effect of galacto-oligosaccharides in rats is dependent of their structural characteristics

AuthorsMarín-Manzano, M. Carmen; Hernández-Hernández, Oswaldo ; Rubio, Luis A. ; Moreno, F. Javier ; Sanz, M. Luz ; Clemente, Alfonso
Issue Date2013
CitationIV Workshop Probióticos, Prebióticos y Salud: Evidencia Científica (2013)
AbstractA comparative study to evaluate the resistance to gut digestion, fermentability and modulatory effect of gut microbiota in the large intestine of growing rats (5 wk old) fed novel galacto-oligosaccharides (GOS) derived from lactulose (GOS-Lu) or commercially available derived from lactose (GOS-La) was performed. Rats were fed either a control (AIN-93G) or experimental diet containing 1% (wt:wt) of GOS-Lu or GOS-La for 14 d. Quantitative analysis of oligomers from dietary and ileal samples demonstrated that the trisaccharide fraction of GOS-Lu was significantly more resistant to gut digestion than that from GOS-La, whereas the disaccharide fraction of GOS-Lu was fully resistant to the extreme environment of the upper digestive tract. The low ileal digestibility rates of GOS-Lu was attributed to the great resistance of galactosyl-fructoses to mammalian digestive enzymes, highlighting the key role played by monomer composition and linkage type involved in the oligosaccharide chain. Di- and trisaccharides were completely fermented within the large intestine, enabling both GOS to have a potential prebiotic function. Indeed, the novel GOS-Lu exerted a stronger bifidogenic effect in large intestine than GOS-La, with the former having a significant and selective increase of Bifidobacterium animalis. In addition, both GOS types showed a significant increase in Eubacterium rectale/Clostridium coccoides population relative to control. These data support a direct relationship between patterns of resistance to digestion and bifidogenic properties of galacto-oligosaccharides.
DescriptionResumen del trabajo presentado al IV Workshop Probióticos, Prebióticos y Salud: Evidencia Científica celebrado en Madrid (España) del 31 de enero al 1 de febrero de 2013.
Appears in Collections:(EEZ) Comunicaciones congresos
(CIAL) Comunicaciones congresos
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