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Cocoa-rich diet attenuates beta cell mass loss and function in young Zucker diabetic fatty rats by preventing oxidative stress and beta cell apoptosis

AutorFernández-Millán, Elisa; Cordero Herrera, Isabel ; Ramos, Sonia ; Escrivá, Fernando; Álvarez, Carmen; Goya, Luis ; Martín, M. Ángeles
Palabras claveGlucose homeostasis
Glutathione enzymes
Pancreas
Type2 diabetes mellitus
Apoptotic pathway
Fecha de publicación2015
EditorWiley-VCH
CitaciónMolecular Nutrition and Food Research 59: 820- 824 (2015)
Resumen© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. We have recently shown that cocoa flavanols may have anti-diabetic potential by promoting survival and function of pancreatic beta-cells in vitro. In this work, we investigated if a cocoa-rich diet is able to preserve beta-cell mass and function in an animal model of type 2 diabetes and the mechanisms involved. Our results showed that cocoa feeding during the prediabetic state attenuates hyperglycaemia, reduces insulin resistant, and increases beta cell mass and function in obese Zucker diabetic rats. At the molecular level, cocoa-rich diet prevented beta-cell apoptosis by increasing the levels of Bcl-xL and decreasing Bax levels and caspase-3 activity. Cocoa diet enhanced the activity of endogenous antioxidant defenses, mainly glutathione peroxidase, preventing thus oxidative injury induced by the pre-diabetic condition and leading to apoptosis prevention. These findings provide the first in vivo evidence that a cocoa-rich diet may delay the loss of functional beta-cell mass and delay the progression of diabetes by preventing oxidative stress and beta-cell apoptosis.
URIhttp://hdl.handle.net/10261/114901
DOI10.1002/mnfr.201400746
Identificadoresdoi: 10.1002/mnfr.201400746
issn: 1613-4133
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